Endocrine Abstracts

The androgen receptor (AR) polymorphism is determined by a variable number of CAG triplets in exon 1 of the AR gene, located on the X chromosome. CAG polymorphism could modulate different hyper- or hypoandrogenic conditions, but its influence on the polycystic ovarian syndrome (PCOS) in different ethnic populations is controversial. Therefore, we investigated the influence of the AR polymorphism on the hormonal factors and clinical signs in 52 women with PCOS and in 41 non-hir...

Androgen receptor (AR) containes a variable polyglutamine chain that is determined by the different number of CAG repeats in the AR gene on the X chromosome. The transactivational competence of AR is inversely related to the length of the polyglutamine chain, respectively to the CAG repeat number. Therefore, we investigated the role of the androgen receptor polymorphism in healthy hirsute and non hirsute women.CAG repeat length polymorphism was analyzed ...